Last updated 17 November 2021
At the end of the 90s the pharmaceutical giant Pfizer introduced to an unsuspecting and sexually reticent world. Blasting its way into global culture, the launch of the ‘little blue pill’ changed how the world talked about and improved the sex lives of millions worldwide.
Coined as the second sexual revolution, Viagra changed impotence from a taboo subject that made sufferers doubt their masculinity into a socially-acceptable subject; one with a solution as simple as swallowing a pill.
Carefully protected by patents, sales of the brand name soared, making Viagra one of the most popular drugs of all time. Despite the arrival of competitors, an onslaught of fake online copies and typically high prices, the dominance of Viagra has remained firm for 15 years.
However all that may be about to change. As Pfizer’s global patents begin to expire, questions are being asked about the effect on their supremacy over the ED marketplace. The UK Viagra patent expires in June 2013, opening up the market to legal generic alternatives. What does this mean for the life cycle of the little blue pill?
Viagra and its meteoric rise to become one of the most recognisable brand-name medications across the world began, like many others, with the fortuitous discovery of an intriguing side effect.
In 1989 a team at Pfizer laboratories in Kent were working on a hypothesis that blocking the enzyme PDE5 would be an effective treatment for symptoms of heart disease, specifically angina. The discovery and synthesis of sildenafil citrate swiftly followed, filed in the manufacturing patent as an experimental compound for heart medication.
Clinical trials investigating high blood pressure and angina began for compound UK-92480, as it was initially referred to. Although the compound was found to have little effect on angina in both phase I and phase II trials, anecdotal evidence from some participants suggested that the drug could stimulate erections. As UK-92480’s prospects of becoming an angina treatment began to fade more volunteers were reporting increased erections, and Pfizer was on the cusp of a significant discovery.
Ian Osterloh, executive director of discovery research at Pfizer remembers the time well in the article “How I discovered Viagra”. He says, “We decided to follow up on these reports to see where it would take us.”
Where it took them was a series of discovery pilot studies for Erectile Dysfunction (ED), which found that a single daily dose was sufficient to produce an erection. “The initial results were encouraging and showed the drug was much more effective than a placebo,” recalls Ian. In response Pfizer launched an accelerated program of study with 21 clinical trials, involving roughly 3,500 men.
“About 12 years after the project had begun, eight years after the first synthesis of UK-92480 and four years after the first ED pilot study, we finally had enough information to be confident of the best dose, and the drug’s safety and effectiveness.”
Pfizer then filed a new drug application with the Food & Drug Administration (FDA) in America who, following a priority review, approved Viagra to treat ED in the US in 1998. The drug was also licenced for use in the UK the same year. This became the first non-surgical treatment for ED and started a fervour that began with an estimated 40,000 prescriptions in the first week and went on to become one of the most famous drugs worldwide.
By the end of 1999, controlling the global market with patents that prevented other drug companies from using not only sildenafil citrate, but even the same class of drug. However this huge piece of the pie was about to be bitten into when a UK ruling opened the doors to competitors.
In 2002, declaring that the scientific knowledge surrounding the key component was already in the public domain. The landmark ruling meant that rival companies would be able to use similar drugs to treat ED, which they quickly leapt on. The following year Viagra’s authority was challenged by the arrival of two ED drugs, and, containing different active ingredients, and respectively.
By 2007 Viagra’s massive share of ED treatment had been affected by both these legal competitors as well as the barrage of counterfeit products and fake copies that filled the internet.
Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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Less common side effects but serious side effects include visual disturbances, hearing changes, or prolonged erections.
Sildenafil is generally not recommended while taking 100mg of it as it can be taken with or without food. If you experience any side effects, contact our pharmacist or your doctor.
17 August, 2020|Holy Winter - Healthcare Writer
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rthirds: -33.Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.
Common side effects reported from Viagra use include:
More severe side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.
As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.
Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.
In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.
Tell them if you haveany heart problems or a history of heart problems, including a recent heart attack or stroke.In addition, let your doctor know if you have recently had a heart attack or circulation problems. If you experience a heart attack or swelling of the eye or eye/eyeercise hand, inform your health care provider immediately. If you experience a heartbeat problem, such as a heartbeat rhythm problem (QT prolongation, for example), inform your health care provider immediately.
deems Viagra prescription drugummies safe for sexual activity because some side effects are severe. This list contains useful information about Viagra. Consult your doctor or pharmacist for more details.List contains common side effects from ViagraAs with all prescription medications, inform your doctor or pharmacist of any medical conditions you currently manage. They may adjust your dose or suggest alternative treatments if you experience severe or persistent side effects.
Common side effects of Viagra
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